Proximity To Discovery

Regenerative Medicine for Diabetes

Newcastle Diabetes has a long and illustrious record in translational research with a world-leading reputation academically, clinically and within industry. Some recent examples of Newcastle’s expertise includes:

  • Pancreatic beta-cell transplantation for Type 1 Diabetes
  • Restoration of endogenous beta-cell function through calorie restriction in established Type 2 Diabetes
  • Potential restoration of beta-cell mass and function in Type 1 Diabetes in early phase immunotolerisation trials at diagnosis
  • Potential reversal of beta-cell dedifferentiation using candidate therapeutic agents
  • Targeting individualised novel diabetes therapies according to rate of beta-cell functional loss within the ‘biomarkers of beta-cell failure’ theme within the Sanofi/EU Innovative Medicines Initiative (IMI) DIRECT Stratified Medicine programme

Please watch the Newcastle Diabetes video which provides an overview of Newcastle’s excellent infrastructure and examples of collaborative translational research towards transformative new therapies for diabetes. The video was prepared for, and initially broadcast at, the American Diabetes Association 75th Scientific Sessions in Boston in June 2015:

NUCOur research benefits from strong links with Newcastle University Curing DIABETES which is a Public and Patient Engagement forum actively engaged in guiding the work we do and charitable fund-raising.

The forum was established following a very generous donation from Mr Ray Wilson who has continued to drive the forum, organising and supporting awareness-raising, wider dissemination and charity events.

A blog will be going live in January 2016 for further information about nucDIABETES and forthcoming charity events.

Other Image  The Regenerative Medicine for Diabetes Group is actively involved in the MRC / BBSRC / EPSRC joint-funded UK Regenerative Medicine Platform as a partner in the Immunomodulation Hub. Please see links below for further details:

http://www.ukrmp.org.uk/hubs/immunomodulation/

http://www.ukrmp.org.uk/2015/11/2015-ukrmp-annual-report-now-available/

LogoClose links are in place with the National Institute for Health Research Blood and Transplant Research Unit (BTRU) in Organ Donation and Transplantation a strategic partnership between the Universities of Cambridge and Newcastle, and their associated transplant units, and NHS Blood and Transplant (NHSBT). The overarching aim of the BTRU is to develop and evaluate novel approaches and technologies that will increase the availability of suitable donor organs for transplantation, while improving graft survival.

To help achieve this we are strengthening existing links and building new collaborations between leading scientists and clinicians to create a BTRU that attracts the best young doctors and scientists and helps them development into the future researchers in transplantation.

http://hospital.blood.co.uk/media/28043/issue-47-18-jan-2016.pdf

Peer-Reviewed Grant Funding

We are also very grateful to Diabetes UK for ongoing grant support for many aspects of our work towards transformative new therapies for diabetes. Please download their 2015-2016 Research Portfolios from their website for more information on all currently funded projects at Newcastle University: https://www.diabetes.org.uk/Research/Our-research-projects/

For further information on Newcastle’s research in regenerative medicine for diabetes please visit: http://www.ncl.ac.uk/icm/research/diabetes/

Find out about the Clinical Pancreatic Islet Transplant programme in Newcastle at the Institute of Transplantation, Freeman Hospital, at: http://www.instituteoftransplantation.nhs.uk/services/islet/

To find out more about the Newcastle Magnetic Resonance Centre and Professor Roy Taylor’s pioneering work on reversing type 2 Diabetes please visit: http://www.ncl.ac.uk/magres/research/diabetes/reversal.htm

For more information about the Sanofi/IMI Direct Stratified Medicine programme please visit: http://www.direct-diabetes.org/

Our facilities in Newcastle include the state of the art NIHR Clinical Research Facility (http://www.ncl.ac.uk/crf/), Magnetic Resonance Centre (http://www.ncl.ac.uk/magres/) and Biomedicine Cellular Therapies Facility (http://www.ncl.ac.uk/ctf/facilities/). Please visit their websites to find out more.

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