Proximity To Discovery

Dermatology

The Dermatology research group at Newcastle University encompasses the full spectrum of translational research from basic cell biology through to disease models, applied clinical studies and clinical trials. There is a strong emphasis on interdisciplinary working and the integration of clinical investigation and basic research as highlighted by a close working relationship between investigators within Newcastle University’s Institute of Cellular Medicine and Institute of Genetic Medicine, and colleagues at Newcastle upon Tyne Hospitals NHS Foundation Trust within the clinical Department of Dermatology at the Royal Victoria Infirmary Hospital, as well as within the Newcastle Centre for Cancer Care.

Investigators in dermatology have a strong focus on translational science, stratified medicine, and collaborative working between industry and academia. This has encompassed various initiatives including

  • Atopic eczema KTP study in partnership with Stiefel/GSK that is leading to a Phase I clinical trial
  • Wellcome Translational Medicine and Therapeutics (TMAT) programme collaboration with Epinova
  • BBSRC funded CASE studentship on atopic eczema models
  • MRC funded Psoriasis Stratification to Optimise Relevant Therapy (PSORT) programme in partnership with GSK

In addition to specific interests and expertise, our cross cutting research themes include:

  • Translational, stratified medicine and early phase clinical studies (in vivo studies, bio-markers, therapeutics)
  • Physiological and pathological cell signalling induced by ultraviolet radiation, wounding/mechanical stress, genetic mutation and the analysis of cellular, mitochondrial, nuclear response
  • Molecular, immunological and systems biology mechanisms in the pathogenesis of inflammatory skin disease, cancer and ageing
  • Stem cell research in the epidermis, non-melanoma and melanoma skin cancers
  • Model systems (genetically modified skin equivalents and fish/animal models)
  • UV irradiation (dosimetry, action spectra and human exposure)
  • Utilization of cutting edge technology including bioimaging (live cell, confocal, high-content, in vivo), flow cytometry, fluorescence activated cell sorting, functional immunology, single cell and next generation sequencing

For further information on Newcastle’s research in Dermatology please visit: http://www.ncl.ac.uk/icm/research/dermatology/

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